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Updated: Aug 27, 2026

Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
Published on: December 15, 2023
Structural embeddedness of social adversity within internalising psychopathology in older adults: A transdiagnostic
Jingying Wang1, Yating Luo2, Sipei Jia2
1Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Xiangya Nursing School, Central South University, Changsha, China.
Background:
Social adversity is a determinant of mental health in later life, yet the network connectivity patterns through which it becomes embedded within internalising psychopathology remain insufficiently understood. This study aimed to examine the transdiagnostic symptom network linking social adversity, psychological resources, and internalising psychopathology in older adults.
Methods:
We conducted a cross-sectional study among older adults in Hunan Province, China. Guided by the Stress Buffering Model, validated self-report measures assessed perceived ageism as social adversity, loneliness and social alienation as interpersonal factors, depression and anxiety as internalising psychopathology, and self-efficacy and life scheme as psychological resources. A Gaussian Graphical Model was estimated using the graphical least absolute shrinkage and selection operator. Expected Influence and Bridge Expected Influence identified central and bridge nodes. Network Comparison Tests examined structural invariance across sociodemographic and clinical subgroups.
Results:
A total of 1225 older adults were included in the analyses. The network showed a highly structured transdiagnostic architecture with a mean predictability of 52.9%. "Apathy and Anxiety" and "Unhappiness" emerged as the most influential nodes. "Somatic Tension Domain" and "Cognitive-Emotional Domain" demonstrated the highest bridge expected influence, connecting social adversity and alienation with depressive symptoms. "Self-Efficacy" and "Life Scheme" showed consistent negative associations with key bridge and depressive nodes. Network structure and global strength remained invariant across major sociodemographic and clinical subgroups.
Conclusions:
Late-life internalising psychopathology was characterised by interconnected network patterns involving social adversity, interpersonal disconnection, anxiety, and depressive symptoms. Anxiety-related domains showed prominent bridge positions linking social adversity with depressive symptoms, while psychological resources were negatively associated with distress-related nodes.
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