Related Experiment Videos
Cardiovascular-Kidney-Metabolic Syndrome in neurological and psychiatric disorders: a large multi-national cohort
Yanqiu Huang1, Kexin Li2, Yang Yangybrbi3
1School of Public Health, Shanghai Jiao Tong University School of Medicine, China; Department of Infectious Diseases and Public Health City University of Hong Kong, China.
Background:
Cardiovascular-Kidney-Metabolic (CKM) syndrome is a pioneering paradigm focused on multisystem homeostasis. Nevertheless, the long-term cerebral manifestations of CKM syndrome and its specific relationship with neuropsychiatric disorders remain poorly understood.
Methods:
Data for the study were obtained from Health and Retirement Study, UK Biobank, China Health and Retirement Longitudinal Study, and National Health and Nutrition Examination Survey. The exposures are continuous CKM stages (stages 0-4). The main outcomes were dementia, Parkinson's disease, depression, anxiety, and sleep disorders. Models were adjusted for demographic characteristics, lifestyle factors, and history of cancer. Proteomic signatures, brain structure, epigenetic aging, and inflammatory markers provided clues to the underlying associations.
Results:
A total of 321,107 participants aged ≥45 years were included in the analysis. Advanced CKM syndrome exhibited higher risks of five disorders (Stage 4 in UK Biobank: HR, 95%CI: 1.91, 1.79-2.04 in dementia; 1.62, 1.45-1.80 in Parkinson's disease; 1.75, 1.66-1.84 in depression; 2.33, 2.18-2.48 in sleep disorders; 1.48, 1.40-1.56 in anxiety). CKM syndrome was associated with accelerated phenotypic aging and reduced volumes in the parietal, temporal, and orbitofrontal lobes. Enrichment analysis identified the "Cytokine-cytokine receptor interaction" pathway as a top enriched pathway in both disease clusters, highlighting the central role of immune-inflammatory signaling. Inflammatory markers, phenotypic aging, and certain proteins (GDF15 and PLAUR) may partly mediate the associations of CKM syndrome with these outcomes.
Conclusions:
Results of this study revealing the robust and persistent association of CKM stages with neurological and psychiatric disorders suggest that early intervention may be important for cognitive performance and emotional well-being in middle-aged and older adults.
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:24Chronic Kidney Disease II: Clinical Manifestations
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...