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Published on: September 11, 2018
Detection of Potential Metabolic and Alcohol-Associated Liver Disease and Alcohol-Associated Liver Disease Using
Mazen Noureddin1, Jörn M Schattenberg2, Rashmee Patil3
1Houston Methodist Hospital, Houston, Texas; Houston Research Institute, Houston, Texas.
Background & Aims:
Accurate distinction between metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and the overlap metabolic and alcohol-associated liver disease (MetALD) is of utmost importance. Due to the potential for underreporting in alcohol use surveys, phosphatidylethanol (PEth) is increasingly utilized in clinical trials to rule out MetALD or ALD. This study examines the prevalence of elevated PEth and its effectiveness in separating phenotypes with dominant MASLD, MetALD, or ALD in the clinical trial setting.
Methods:
A multicenter database of patients screened for enrollment in clinical trials for MASLD pharmacologic therapies was reviewed, from which patients with PEth results were identified, then further stratified into low (<20 ng/mL), moderate (20-<100 ng/mL), or high (≥100 ng/mL) alcohol intake groups.
Results:
Among 2870 patients with baseline PEth data, 2560 (89%) had low, 168 (6%) had moderate, and 142 (5%) had high PEth levels, including 92 with PEth ≥200 ng/mL. Higher hemoglobin A1C was associated with lower PEth (P < .001). Aspartate aminotransferase (P < .001), alanine aminotransferase (P < .001), and γ-glutamyltransferase (P < .001) were elevated in patients with higher PEth results. Indeterminate Fibrosis-4 scores were more prevalent in patients with PEth ≥100 ng/mL (P < .001). In multivariable analysis, PEth ≥20 ng/mL was associated with higher γ-glutamyltransferase (per 10 U/L; adjusted odds ratio, 1.04; 95% confidence interval, 1.03-1.06; P < .001), and lower hemoglobin A1C (adjusted odds ratio, 0.68; 95% confidence interval, 0.60-0.78; P < .001).
Conclusions:
In this prospective multicenter cohort of participants screened for MASLD clinical trials with systematically collected PEth, 11% had PEth ≥20 ng/mL, suggesting a level of alcohol consumption that may warrant further clinical evaluation for possible MetALD or ALD.
