Pilot: Wnt signaling controls pgam2 expression in zebrafish cardiomyocytes

The relationship between developmental signaling pathways and basal metabolism in zebrafish hearts is still unexplored. Given the key role of canonical Wnt signaling in zebrafish cardiac development, our study analyzes the responsiveness to Wnt of phosphoglycerate mutase 2 ( pgam2 ), which catalyzes the glycolytic conversion of 3-phosphoglycerate to 2-phosphoglycerate. Notably, Pgam2 emerged as a gateway between glycolytic and cholesterol metabolism for its intersection with ATP generation within the cell. Since Pgam2 is linked to overall metabolic homeostasis and multiple cardiovascular diseases (CVDs), it represents a perfect candidate to dissect the Wnt involvement in the basic metabolism of developing cardiomyocytes.