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Updated: Aug 27, 2026

Development of Mesenchymal Stem Cell Membrane-Enveloped Nanovesicles for Enhanced Gene Delivery
Published on: February 17, 2026
Advances in the development and delivery of nucleic acid-based therapeutics
Ellise Kurczewski1, Aslan Mansurov2, Chirag Sachar3
1The Biological Sciences Division and The Booth School of Business, The University of Chicago, 5807 S. Woodlawn Ave, Chicago, IL 60637, USA. ekurczewski@uchicago.edu.
Abstract:
Recent advancements in experimental and computational methods along with growing gene sequencing libraries have enabled rapid development of nucleic acid-based therapeutic design for a wide variety of diseases. New drugs, delivery tools and methods have enabled precise and efficient therapy at a molecular scale. This review covers the current landscape and future directions of methods for gene and cell therapies, as well as their applications, advantages, and limitations. We present self-amplifying RNA, circular RNA, CRISPR systems, antisense oligonucleotides, and antibody-oligonucleotide conjugates, as well as CAR modification of T-cells, natural killer cells, and macrophages, with a brief discussion of modified stem cells. We also discuss developments in viral and non-viral delivery systems for their applications in cell and gene therapies.
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