Clinical Patterns, Complications, and Long-Term Visual Outcomes of Fuchs' Uveitis Syndrome in Turkish Population:...

In this study, we aimed to characterize the clinical presentation patterns, complications, and visual prognosis of Fuchs' uveitis syndrome (FUS) patients at a tertiary center in Türkiye.

Sixty-one FUS patients (64 eyes) were enrolled in this retrospective study. Detailed ophthalmic and systemic history was obtained from patients at the initial examination. Visual acuity measurement (decimal values, converted to logarithm of the minimum angle of resolution [logMAR]), slit lamp examination, dilated fundus examination, intraocular pressure measurement with Goldmann applanation tonometry were performed at each visit.

Keratic precipitates (KP) were present in 57 eyes (89.06%) at initial examination. Diffuse small stellate greyish KPs were observed in 50 eyes (78.13%). Thirty eyes (46.88%) presented with heterochromia. Twenty-seven eyes (42.19%) had vitreous debris/fibrillary appearance or condensation. The most common complication was cataract (79.69%), of which the most common type was posterior subcapsular cataract. At presentation, anterior chamber cells were seen in 32 eyes (50%). The mean visual acuity was 0.28±0.56 logMAR at the first examination and 0.25±0.48 logMAR at the final examination (p=0.542).

According to our findings, unilateral uveitis accompanied by low-grade anterior chamber inflammation, diffuse small stellate KPs, and diffuse stromal iris atrophy, with or without vitreous debris, remains the most characteristic clinical presentation among patients with FUS. Iris findings such as heterochromia and iris nodules are less frequently observed in Turkish patients, likely due to ethnic variations.