Related Experiment Video
Updated: Aug 27, 2026
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Body roundness index, frailty, and prevalent self-reported stroke: An exploratory cross-sectional decomposition
Zekai Hu1,2, Jie Zhuang1, Jinyan Wang1
1The Second Rehabilitation Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Department of Rehabilitation Medicine, Shanghai, China.
Introduction:
Prior NHANES studies have reported nonlinear associations of the body roundness index (BRI) with prevalent stroke and frailty. The authors updated these observations using NHANES 1999-2023 and examined the additional contribution of frailty to the BRI-prevalent self-reported stroke association.
Method:
This cross-sectional study included 36,324 adults. Stroke was defined by self-reported physician diagnosis. Survey-weighted logistic regression and restricted cubic splines were used to assess BRI associations. Expanded models were fitted with and without the frailty index (FI). A post hoc 2-piecewise model estimated a potential BRI breakpoint using 1000 bootstrap resamples. Incremental discrimination was evaluated across nested age-sex, age-sex-BRI, and age-sex-BRI-FI models. Analyses were interpreted as cross-sectional associations.
Results:
In the primary adjusted model, higher BRI was associated with prevalent self-reported stroke (odds ratio [OR]=1.08, 95% confidence interval [CI] 1.05-1.12). The spline showed increasing odds across lower-to-middle BRI values, followed by attenuation at higher values. The exploratory breakpoint was 6.34 (bootstrap 95% CI 6.14-7.65). In expanded sensitivity analyses, the BRI estimate was attenuated without FI (OR=1.01, 95% CI 0.98-1.04) and became inverse after FI was included (OR=0.91, 95% CI 0.88-0.95). FI remained strongly associated with prevalent self-reported stroke (OR=2.38 per 0.1-unit increase, 95% CI 2.23-2.54). Adding BRI to age and sex increased area under the curve (AUC) from 0.763 to 0.769, while adding FI increased AUC to 0.868.
Conclusion:
BRI showed a nonlinear, model-dependent association with prevalent self-reported stroke, and frailty provided additional cross-sectional information. These findings support prospective evaluation of BRI and frailty as complementary markers in stroke-related assessment.
