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Functional Lumen Imaging Probe (EndoFLIP) in Upper Gastrointestinal Disorders: Current Evidence, Clinical
Theodoros A Voulgaris1, Dimitrios I Ziogas1,2, Ioannis Stasinos3
1Department of Endoscopy, Second Academic Surgical Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece.
Abstract:
The Functional Lumen Imaging Probe (EndoFLIP®) system is an impedance-based technology providing real-time measurements of cross-sectional area (CSA) and intraballoon pressure across a luminal segment. Initially developed for esophagogastric junction (EGJ) evaluation in achalasia, the application of EndoFLIP has subsequently expanded to the assessment of both sphincteric and non-sphincteric regions throughout the gastrointestinal tract in a variety of clinical conditions, including eosinophilic esophagitis (EoE), post-fundoplication states, and gastroparesis. Its unique ability to be utilized in both the diagnostic and therapeutic settings, including the assessment of treatment response, makes it a valuable tool in the overall management of gastrointestinal motility disorders. The present review extends beyond a simple overview of EndoFLIP applications by providing a comprehensive evaluation of its performance in comparison with other diagnostic modalities, as well as the current knowledge gaps regarding its use. Study limitations and procedure-related aspects requiring further investigation are critically discussed, with the aim of supporting and guiding future research in this field.
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