Related Experiment Video
Updated: Aug 28, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Gut Limosilactobacillus reuteri-secreted Components Mitigate Susceptibility to Radiation by Alleviating Oxidative
Hyeyun Kim1, Se-Hui Lee1, Sun Park1
1Department of Integrated Biological Science, Pusan National University, Busan, 46241, Korea.
Abstract:
Radiotherapy is the most effective method to eliminate several types of cancer; however, radiation-induced intestinal damage, such as epithelial cell apoptosis, remains a perennial problem. The study revealed that the feces of mice surviving exposure to 7.5 Gy ionizing radiation (IR) originally harbored higher levels of Lacticaseibacillus casei, Lactobacillus salivarius (LS), and Limosilactobacillus reuteri (LR) than those in the commensal bacteria of dead mice. While mice pre-inoculated with LS and LR for 8 weeks showed protective efficacy against 7.5 Gy IR, mice pretreated with LR-Secreted Components (LR-SCs) for 7 days demonstrated lesser epithelial damage and susceptibility to high IR doses than those of LS-SC treated mice. LR-SC treatment also regulated the increased levels of IR-induced cellular reactive oxygen species levels in intestinal epithelial cells. In summary, LR-SCs are potential prophylactic agents to alleviate the side effects of radiotherapy in patients with cancer.
Related Concept Videos
Other Unique Bacteria
Microbiota Modulation by Antibiotics
Dysbiosis of the Gut Microbiota
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease II: Ulcerative Colitis
Drugs for Treatment of Ulcerative Colitis in IBD
