Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remyelination in multiple sclerosis.

J W Prineas, F Connell

    Annals of Neurology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Remyelination by oligodendrocytes occurs in the adult central nervous system (CNS) and is common in multiple sclerosis (MS) plaques. This study found evidence of remyelination at the edges of chronic plaques in MS patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2011
    Same author

    IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign.

    Molecular syndromology·2010
    Same author

    A new classification system for primary lymphatic dysplasias based on phenotype.

    Clinical genetics·2010
    Same author

    MS: is it one disease?

    International MS journal·2009
    Same author

    The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2006
    Same author

    Immunopathology of secondary-progressive multiple sclerosis.

    Annals of neurology·2001

    Area of Science:

    • Neuroscience
    • Pathology
    • Cell Biology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS).
    • Demyelination and remyelination are key pathological processes in MS.
    • Understanding remyelination is crucial for developing therapeutic strategies.

    Purpose of the Study:

    • To investigate evidence of remyelination in chronic plaques of multiple sclerosis (MS) lesions.
    • To characterize the morphological features of abnormal myelin sheaths at the plaque margins.

    Main Methods:

    • Electron microscopy examination of central nervous system (CNS) tissue.
    • In situ perfusion fixation of tissue from two multiple sclerosis patients.
    • Analysis of myelin sheath morphology in chronic plaques.

    Related Experiment Videos

    Main Results:

    • Abnormal central myelin sheaths were observed at the margins of most MS plaques.
    • Common findings included bare axon segments, thin paranodes, and variable internode thickness.
    • Abnormally thin, uniformly thick internodes with normal nodal complexes were frequently found at plaque edges.

    Conclusions:

    • The presence of specific remyelinated internode types indicates oligodendrocyte-mediated remyelination in the adult human CNS.
    • Remyelination is a common, albeit limited, process in some cases of multiple sclerosis.
    • These findings support the potential for endogenous repair mechanisms in MS.