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Virtual Cell Challenge 2026: Benchmarking zero-shot generalization across cellular contexts
1Arc Institute, Palo Alto, CA, USA; University of California, San Francisco, San Francisco, CA, USA.
Cell
|August 26, 2026
Abstract:
The Virtual Cell Challenge returns in 2026 with a more demanding test of biological generalization: zero-shot prediction across multiple independent cellular contexts. Participants will build models to predict gene knockdown responses in a new Arc-generated dataset comprising unseen cell lines. The goal is to determine whether the best models can meaningfully close the gap between preclinical experimental predictions and human biology.
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