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Updated: Aug 28, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
From DNA-Encoded Chemistry to Tumor-Targeted Small Molecule Therapeutics
Samuele Cazzamalli1, Dario Neri1,2,3
1R&D Department, Philochem AG, CH-8112 Otelfingen, Switzerland.
Abstract:
Unlike conventional screening methods, which are limited by library size, DNA-encoded chemical library (DEL) technology enables the simultaneous interrogation of billions of compounds, each uniquely barcoded with DNA tags. These libraries can be screened through affinity-based capture and decoded using high-throughput sequencing. DEL-derived ligands can be conjugated to cytotoxic agents or radioactive isotopes, facilitating the creation of highly selective therapeutics that target diseased cells while minimizing off-target effects. This article explores the use of DELs for identifying high-affinity small organic ligands for the development of small molecule-radio conjugates (SMRCs) and small molecule-drug conjugates (SMDCs).
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