Related Experiment Video
Updated: Aug 28, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
SDHB and CDK1 protein expression in metastatic pheochromocytoma and paraganglioma
Lisa Gunnesson1,2, Sinan Karakaya3,4,5, Sofie Mohlin3,4,5
1Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden.
Background:
Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential.
Aim:
The aim of this study was to investigate whether SDHB and CDK1 expression is associated with metastatic capacity in PPGL.
Material And Methods:
A tissue microarray (TMA) was constructed from 175 tumors from a total of 149 unique PPGL patients treated at Sahlgrenska University Hospital. SDHB, CDK1, and proliferation index Ki-67 were assessed and correlated to metastatic capacity defined as a confirmed metastatic event.
Results:
Negative SDHB expression was more common in patients with metastatic PPGL and displayed a trend toward lower overall survival and correlation with higher Ki-67%. High CDK1 expression was not associated with any of the parameters mentioned above.
Conclusion:
Negative SDHB expression but not high CDK1 expression is associated with metastatic capacity in PPGL.
Related Concept Videos
02:34Inhibition of Cdk Activity
02:23Abnormal Proliferation