Consanguinity-Associated Genetic Disorders in Saudi Arabia: A Hypothesis on the Future Role of CRISPR-Based Gene...

Background Consanguineous marriage remains highly prevalent in Saudi Arabia and is strongly associated with increased rates of inherited genetic disorders, including sickle cell disease and β-thalassemia. The persistence of such marriages, driven by cultural and social factors, limits the effectiveness of existing preventive strategies such as premarital screening and genetic counselling. Methodology A cross-sectional, survey-based study was conducted between November and December 2025 among 139 participants across Saudi Arabia. The questionnaire was distributed via WhatsApp messaging groups and administered using Google Forms. The 17-item survey covered CRISPR awareness, perceptions of consanguinity and genetic disease risk, and attitudes toward CRISPR as a therapeutic intervention. Data were analysed using descriptive statistics. Results Of 139 participants, 60.4% had previously heard of CRISPR; however, 55.4% demonstrated limited or no meaningful knowledge of the technology. Despite this, 96.4% expressed willingness to accept CRISPR-based treatment for inherited genetic disorders. Scientific safety, religious considerations, and cost were the most frequently cited factors influencing acceptance. Conclusions Public awareness of CRISPR in Saudi Arabia remains critically low despite high receptiveness to its therapeutic applications. Integrating targeted public education with CRISPR-based somatic cell interventions could represent an effective long-term strategy for reducing the burden of inherited genetic disorders associated with consanguineous marriage in Saudi Arabia.