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Updated: Aug 28, 2026
Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy
Published on: April 8, 2018
Long-Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C
Kotaro Sakaya1,2, Akira Ishiguro1,2,3, Atsushi Sakamoto1,2
1Department of Pediatrics, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Abstract:
Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single-center case series of three pediatric patients with severe congenital PC deficiency who underwent liver transplantation (LT). In all patients, plasma PC activity levels exceeded 64% after LT and remained stable without anticoagulation treatment or PC supplementation. Two patients were followed for more than 10 years, representing the longest reported outcomes to date. Stable anticoagulant function persisted despite rejection, graft dysfunction, and subsequent surgery, demonstrating durable restoration of physiological anticoagulant function after LT.
