Related Experiment Video
Updated: Aug 28, 2026
The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Aggressive Mandibular Squamous Cell Carcinoma Mimicking Periodontal Disease in a Non-Transplanted Patient With
Cassius Carvalho Torres-Pereira1, Laura Grein Cavalcanti1, Marta Aparecida Alberton Nuernberg1
1Department of Stomatology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.
Background:
Fanconi anemia (FA) is associated with markedly increased risk for early-onset oral squamous cell carcinoma (OSCC).
Methods:
We report an aggressive mandibular squamous cell carcinoma in a 26-year-old non-transplanted woman with FA initially interpreted as localized periodontal disease adjacent to a tongue leukoplakia.
Results:
Initial examination demonstrated mild gingival inflammation and localized alveolar bone loss involving the right mandibular molars. Forty-five days later, the patient returned with facial asymmetry, severe bone destruction, and grade III tooth mobility. Cone beam computed tomography revealed extensive mandibular osteolysis, and biopsy confirmed squamous cell carcinoma with extensive intraosseous involvement. Despite surgical treatment, the patient died 3 months later.
Conclusions:
This case highlights the potential limitations of surveillance strategies focused predominantly on visible mucosal lesions and reinforces that rapidly progressive periodontal-like destruction in patients with FA should raise immediate suspicion for malignancy.
More Related Videos
05:42Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
Published on: August 11, 2023
04:04Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025