Related Experiment Video
Updated: Aug 28, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Detection of Common Thoracic Abnormalities with 0.55-T Lung MRI Compared with Chest CT: A Reader Performance Study
Felicia Tang1, Timothy Chen1, Sayedomid Ebrahimzadeh1
1Division of Cardiac and Pulmonary Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143.
Abstract:
Purpose To assess image quality and detection performance of 0.55-T MRI for common lung pathologies in a multireader study. Materials and Methods Twenty-eight participants were prospectively enrolled at a tertiary academic medical center between January 1, 2023, and August 31, 2023, and underwent same-day chest CT and 0.55-T MRI with respiratory-triggered T2-weighted axial BLADE and T1-weighted ultrashort echo time sequences. Six radiologists evaluated the quality of the MRI using a Likert-type scale and assessed common lung abnormalities. Sensitivity was calculated as the proportion of CT-confirmed lesions detected on MRI and was compared between readers by training status using the Kruskal-Wallis test. Fleiss κ values were calculated for interreader agreement. Nodule measurements were compared between modalities using the Pearson correlation coefficient. Results Twenty-eight participants (mean age ± SD, 59 years ± 19; 17 female) were included. The overall quality of 80% (134 of 168) of the images was scored as good or higher. 0.55-T MRI achieved sensitivities of at least 85% for consolidations and large solid nodules (≥6 mm) and less than 40% for emphysema, ground-glass nodules, and small nodules (<6 mm). Readers achieved moderate agreement in lesion detection (κ, 0.51; 95% CI: 0.37, 0.61), with no evidence of a difference in sensitivity when stratified by training level (P = .56). Nodule size at CT and MRI was strongly correlated (r = 0.79-0.95; P < .001). Conclusion Consolidation and large solid nodules were well detected on 0.55-T MRI, whereas the detection performance for small nodules, ground-glass nodules, and emphysema was limited. Keywords: MR-Imaging, MR-Diffusion Weighted Imaging, Thorax, Lung, Mediastinum, Pleura, Pulmonary Arteries, Imaging Sequences, Observer Performance, Technology Assessment Supplemental material is available for this article. © RSNA, 2026.
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