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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis06:26

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Mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD) with metabolic dysfunction, hepatic gene expression changes, and liver histopathological alterations that resemble human MASLD, including fibrosis that progresses to advanced fibrosis stage 3. This model can be used in studies of MASLD pathophysiology and in pre-clinical studies of new therapies.
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Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete09:45

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This protocol describes in vitro cultivation of the syphilis pathogen Treponema pallidum subsp. pallidum in co-culture with mammalian cells. The method is scalable; it can be used to produce large quantities of T. pallidum and to generate clonal...
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Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Liver disease in early syphilis.

D Campisi, C Whitcomb

    Archives of Internal Medicine
    |March 1, 1979
    PubMed
    Summary

    Early syphilis can cause hepatitis, presenting diagnostic challenges. Key indicators include perianal lesions and elevated alkaline phosphatase, responding to syphilis treatment.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Syphilology

    Background:

    • Atypical presentations of early syphilis can complicate diagnosis and treatment.
    • Hepatitis is an uncommon but significant complication of early syphilis.

    Observation:

    • Two cases of hepatitis complicating early syphilis are presented.
    • Diagnostic clues for syphilitic hepatitis include perianal lesions and disproportionate elevations in serum alkaline phosphatase.
    • Liver biopsy results were nonspecific.

    Findings:

    • The primary differential diagnosis for syphilitic hepatitis is hepatitis B with false-positive serologic results.
    • Liver function abnormalities associated with syphilitic hepatitis resolve with standard treatment for secondary syphilis.

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    Implications:

    • Recognizing atypical syphilitic hepatitis is crucial for timely and appropriate patient management.
    • Close follow-up of patients and their contacts is essential for disease control and preventing transmission.