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Updated: Aug 29, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Laser-Assisted Photodynamic Therapy for Proliferative Verrucous Leukoplakia: a Case Report
Shangjun Zhang1, Tingting Ding1, Yining Li1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, PR China.
Abstract:
Proliferative verrucous leukoplakia (PVL) is an uncommon but highly aggressive oral potentially malignant disorder, characterized by a high rate of malignant transformation and notable resistance to conventional treatments, including surgery, laser ablation, and systemic agents. Herein, we present a case of PVL in a 60‑year‑old female with no history of tobacco, alcohol, or betel nut consumption. The lesion, situated on the left buccal mucosa, was treated with laser‑assisted photodynamic therapy (PDT). Following two sessions, the lesion resolved completely, with no recurrence during a 20‑month follow‑up. This case report reinforces the limited evidence advocating PDT as a viable alternative for PVL, particularly when combined with laser pretreatment to circumvent the impediment posed by lesion hyperkeratosis.