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Updated: Aug 29, 2026

Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection
Published on: September 18, 2020
Neutrophil-T cell dynamics predict tuberculosis outcome
Maziar Divangahi1, Erwin Schurr2
1Meakins-Christie Laboratories, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; McGill International TB Centre, Montreal, Quebec, Canada; The Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Department of Microbiology and Immunology, Montreal, Quebec, Canada.
Abstract:
Most individuals infected with Mycobacterium tuberculosis never develop active disease, yet the airway immune events determining outcome remain poorly understood. Branchett and colleagues prospectively profiled bronchoalveolar lavage from recent tuberculosis contacts, revealing that progression reflects a dynamic competition between opposing local immune states rather than a single immunological failure.
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