Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth

Management of immature permanent teeth with pulp necrosis remains a clinical challenge due to incomplete root development and limitations of conventional endodontic approaches. Therefore, it is of interest to evaluate the clinical and radiographic efficacy of regenerative endodontic procedures using platelet-rich fibrin compared with mineral trioxide aggregate apexification in 40 immature necrotic teeth. Patients were randomly allocated into two groups and assessed clinically and radiographically using periapical radiographs and CBCT at 3, 6 and 12 months. The platelet-rich fibrin group demonstrated significantly greater improvement in root length, dentinal wall thickness and apical closure compared to the apexification group, with higher clinical success rates. Regenerative endodontic procedures using platelet-rich fibrin appear to be more effective in promoting root maturation and periapical healing in immature necrotic teeth.