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Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications
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Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation

Shan Hu1, Xiaoying Lian1, Jinnawat Jongkhumkrong1

  • 1Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.

Nature Chemistry
|August 28, 2026
PubMed

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
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