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Updated: Aug 30, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
Published on: August 29, 2020
Mechanistic Study of m5C Modification in Stem Cell Differentiation and Disease Regulation
Xiangrong Zhang1,2, Jianqiao Li1, Zhifeng Zhang1
1Hebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China.
Abstract:
m5C (5-methylcytosine) modification is a significant epigenetic modification in RNA that has garnered substantial attention in recent years in stem cell biology and disease research. The dynamic regulation of m5C involves methyltransferases, demethylases, and specific binding proteins, which collectively influence RNA stability, translation efficiency, and cellular function. Especially in stem cell differentiation, m5C modification not only affects stem cell self-renewal and differentiation fate but is also closely associated with the onset and progression of various diseases. This review explores the mechanisms of m5C modification in stem cell differentiation and related diseases, highlighting its emerging roles in gene expression regulation and disease pathogenesis. CLINICAL TRIAL NUMBER: Not applicable.
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