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Updated: Aug 30, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
Published on: January 6, 2014
Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma
María Cruz Cobo1, Laure Garnier1,2, Marion Mandavit1
1Geneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Summary:
Cruz Cobo et al. identify small molecules that reprogram dendritic cells toward an immuno-stimulating secretory phenotype, revealing endoplasmic reticulum calcium signaling as a druggable axis to boost vaccine-based and T cell-mediated cancer immunotherapies. The study links broad changes in calcium-induced secretion to improved immune activation and therapeutic potency.
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