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The Role of 1-3-Beta-D-Glucan in Predicting Pneumocystis jirovecii Pneumonia in Immunocompromised Children
Markus Keldorfer1, Raphael Ulreich1, Johann Martensen1
1Pediatric Intensive Care Unit, Department of Children and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Journal of the Pediatric Infectious Diseases Society
|August 29, 2026
Abstract:
Serum 1,3-β-D-glucan (BDG) showed high negative predictive value (~99%) for Pneumocystis jirovecii pneumonia (PJP) in 106 non-human immunodeficiency virus immunocompromised children, but modest positive predictive value at low prevalence. These exploratory findings suggest BDG may help exclude PJP, pending prospective validation.
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