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Updated: Aug 31, 2026

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
Published on: May 11, 2017
POC1A colocalizes with POC1B in human and bovine spermatozoa centrioles
Robert Heizelman1, Yash Dixit1, Derek Kluczynski1
1University of Toledo, Toledo, OH, US.
Abstract:
Infertility impacts one in seven couples globally, with one-third of cases classified as unexplained. One source of unexplained infertility is the spermatozoon centrosome, a subcellular structure composed of two remodeled centrioles (the proximal and distal centrioles) and specialized pericentriolar material, located in the spermatozoon neck. The centrosome functions as the head-neck linker in the spermatozoa. Here, we investigated the localization of the somatic cell centriole lumen protein POC1A using immunofluorescence and confocal microscopy. We found that POC1A localizes to the neck, colocalizing with POC1B, and is present in both the proximal and distal centrioles in both human and bovine spermatozoa.
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