Related Experiment Video
Updated: Aug 31, 2026

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
Published on: June 9, 2023
The Problem of Temporal Misalignment in Longitudinal Causal Research
Jeroen D Mulder1, Manuel C Voelkle2, Ellen L Hamaker1
1Universiteit Utrecht, Utrecht, The Netherlands.
Abstract:
A common goal of longitudinal research in psychology and related disciplines is the study of causal effects over time. An often overlooked assumption in this context is temporal alignment, referring to a match between the timescale at which a longitudinal process operates, the timescale at which data were collected, and the time frame in measurements. We present multiple scenarios, representing both the analysis of intensive longitudinal data and panel data, in which this assumption is violated due to time aggregation (i.e., aggregating scores over multiple occasions) and/or systematic undersampling (i.e., measurement intervals that are too long in relation to the longitudinal process). Our simulations demonstrate the large biases that can occur in estimates of lag-0 and lag-1 effects using various modeling approaches, even when there is no effect in the data. We discuss implications of these results and briefly consider future lines of methodological research to address this problem.
More Related Videos
Related Concept Videos
Longitudinal Research
Longitudinal Studies
Causality in Epidemiology
Confounding in Epidemiological Studies
Cause and Effect
Assumptions of Survival Analysis

