Related Experiment Video
Updated: Sep 2, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Adverse policing as a social exposome pathway: Implications for depression, cognition, and dementia risk
Erika Pugh1, Muriel Taks Calle2, Ganesh M Babulal3,4,5
1Department of Psychiatry and Behavioral Health, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Introduction:
The social exposome is increasingly recognized as a key determinant for cognitive health. Adverse policing represents an understudied aspect of the social exposome, reflecting persistent encounters with punitive surveillance and law enforcement that accumulate as chronic structural stressors across the life span.
Methods:
Using data from the Health and Retirement Study (2006-2020), we performed exploratory and confirmatory factor analyses to examine the dimensional overlap between depressive symptoms and cognitive performance among older Black adults aged 65 + (n = 265; mean age = 69; 72% women), stratified by adverse policing exposures.
Results:
Depressive and cognitive items generally formed separate dimensions, with effort-related depressive items and cognitive performance items frequently co-loading, suggesting an intermediate latent factor linked to psychosocial burden.
Discussion:
Our findings underscore the importance of integrating social exposome exposures, such as adverse policing, into modelling dementia risk. This will help researchers better characterize how social adversity impacts cognitive health.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
The Influence of Cognition on Affect
Dementia
The progression of dementia is generally gradual.
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Dementia l: Introduction