Granular cell tumour in tracheobronchial tree: Two case presentations with different outcomes

The lung's granular cell tumour (GCT) is a rare neoplasm originating from Schwann cells. GCT often grows in various sites and can be benign or malignant. Only 2-6% of GCTs occur in a tracheobronchial tree. We aim to present two cases of tracheobronchial GCT. A 68-year-old man had multiple endobronchial GCTs, while a 54-year-old woman had one endotracheal nodule of GCT. GCTs consist of submucosal infiltrates, round to oval cells, with abundant granular cytoplasm positive for S100 (2/2), NSE (2/2), and CD68 (2/2). One of the patients had a GCT on the right, treated by bronchoscopic extirpation and associated with acinic adenocarcinoma on the opposite side, which was diagnosed after the lobectomy on the right. Other patients had a tracheal GCT with fatal outcomes on the tenth day after the surgery due to the development of acute pulmonary oedema, which was confirmed at autopsy. Tracheobronchial GCT has a broad spectrum of clinicopathological symptoms and signs with different outcomes.