[Design and Implementation of a Dual-Mode Focused Ultrasound Treatment System]

This study presented the design, and preliminary validation of a dual-mode focused ultrasound system for thermal ablation and histotripsy based on a single transducer. The acoustic characteristic measurements indicated that the maximum acoustic power was approximately 185 W in thermal ablation mode and exceeded 6 000 W in histotripsy mode. Under different treatment parameters, the ex vitro experimental results demonstrated that the system could achieve coagulative necrosis through thermal ablation and liquefaction through histotripsy, which disintegrates tissue into homogenate, respectively. Therefore, this system can be used for preclinical research on the thermal and mechanical effects of focused ultrasound.