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Updated: Sep 2, 2026
Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells
Published on: April 25, 2014
Malignant Transition in Three Dimensions
Zehua Jing1, Mingyao Li1,2
1Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Abstract:
Breast and prostate cancers share notable similarities in their progression to invasive disease, providing a unique opportunity to uncover common mechanisms of malignant transition. By integrating volumetric reconstruction with multimodal spatial profiling, Storrs and colleagues revealed the precancer-to-cancer transition as a continuous three-dimensional process and identified shared molecular programs associated with invasion. See related article by Storrs et al., p. 1819.
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