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Published on: May 2, 2025
Fabrication of ROS-responsive puerarin-loaded HA/PCL small-diameter vascular grafts for accelerated in situ
Shuang Wang1, Xinbo Wei1, Moyan Zhou1
1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. haifengliu@buaa.edu.cn.
Abstract:
Cardiovascular diseases continue to exhibit high global morbidity and mortality rates, driving urgent demand for the development of small-diameter (diameter < 6 mm) vascular grafts. Current small-diameter vascular grafts exhibit low patency rates in vascular reconstruction due to incomplete endothelial coverage. The design of vascular grafts with spontaneous endothelialization is critically needed. Herein, we developed an on-demand ROS-responsive polycaprolactone (PCL) graft modified with puerarin (PUE) and hyaluronic acid (HA) by electrospinning. In this study, PCL mimicked the structure of native blood vessels, and PUE-HA encouraged the antioxidation and endothelialization of vascular grafts with improved biocompatibility. The PUE-HA-PCL graft could promote the adhesion and proliferation of endothelial cells (ECs) and facilitate the process of tissue regeneration. Moreover, the grafts remained completely unobstructed with well-organized elastin fibers for 3 months after implantation. Taken together, the results effectively demonstrate that PUE-HA-PCL will be a promising functional small-diameter vascular graft with spontaneous endothelialization.
