[Clinical And Therapeutic Characteristics Of Gestational Trophoblastic Tumors In The Point G's University Hospital]

Gestational trophoblastic tumors (GTT) are heterogeneous tumors characterized by trophoblast involvement with an abnormal increase in human chorionic gonadotropin (HCG). The aim of this study was to describe in our context, the clinical, diagnostic, therapeutic characteristics and poor prognostic factors influencing the survival of these tumors.

This was a descriptive study of 90 patients followed for GTT at the Point G University Hospital between August 2007 and May 2020. Clinical, paraclinical and therapeutic data were collected retrospectively from the medical records of these patients and analyzed by SPSS version 21 software.

The mean age of the patients was 31 years ± 10.08 (15-54 years) with a peak frequency between 20-40 years. The clinical picture was frequently dominated by the following symptoms: metrorrhagia (97.8%), anemia (86.7%) and poor Performans Status (PPS) (42.2%). The mean βHCG level was 589,394.15 U/l and choriocarcinoma was the most common histological type -64.9%-. The disease was metastatic in 46.7% with a FIGO 2000 (Fédération Internationale de Gynécologie-Obstétrique) prognostic score of high risk in 57.8%. Regardless of this score, 92.7% underwent polychemotherapy. Only 41.1% of patients were alive at the end of the study. Poor prognostic factors associated with decreased overall survival were WHO PS 2-4, grade 2-4 anemia, high-risk prognostic score, and resistance to chemotherapy, all of which indicate delayed management.

Despite their chemosensitivity, GTT may have a poor prognosis if their diagnosis is late and their management is not adapted.