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Primary breast diffuse large B-cell lymphoma mimicking breast carcinoma: a case report
Renda Jiang1, Dalei Chen1, Luning Wu1
1Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University, Dongyang, China.
Background:
Primary breast lymphoma (PBL) is an exceedingly rare extranodal malignancy that frequently mimics breast carcinoma on clinical and radiological examination, posing a significant diagnostic challenge.
Case Presentation:
We report a case of a 39-year-old Chinese woman who presented with two palpable right breast masses. Imaging revealed suspicious lesions classified as Breast Imaging-Reporting and Data System 4A, prompting surgical excision and biopsy. Histopathological examination and immunohistochemical (IHC) analysis confirmed a diagnosis of diffuse large B-cell lymphoma, germinal center B-cell subtype. Staging by 18F-fluorodeoxyglucose positron emission tomography/computed tomography established disease as Ann Arbor stage IE, asymptomatic (stage IEA) with an International Prognostic Index score of 0. The patient was initiated on R-CHOP chemoimmunotherapy and demonstrated a favorable response after three cycles, with no evidence of recurrence.
Conclusion:
This case highlights the importance of histopathological and IHC evaluation in differentiating PBL from breast carcinoma. Early and accurate diagnosis is essential to guide appropriate treatment and optimize patient outcomes.
