Related Experiment Video
Updated: Sep 2, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Impact of SLCO1B3 767G>C (rs60140950) polymorphism on paclitaxel response in Iraqi women with breast cancer
Balsam S J Al-Hussein1, Atheer M R Al-Juhaishi2, Hassan M M Abo Almaali3
1Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Karbala, Iraq.
Objective:
The aims of this study were to identify genetic polymorphism in solute carrier organic anion transporter 1B3 (SLCO1B3 767G>C (rs60140950)), and to examine the impacts of this polymorphism on the efficacy and safety of paclitaxel in Iraqi women with breast cancer (BC).
Methods:
This cross-sectional observational study involved 150 women with BC who were administered paclitaxel. During the second week of paclitaxel therapy, these women were evaluated individually using a questionnaire to gather demographic information, such as their age and body mass index, as well as the likelihood and intensity of adverse effects of paclitaxel. Neutropenia levels and BC biomarkers were also evaluated.
Result:
The wild-type genotype of the SLCO1B3 767G>C genetic polymorphism was identified in approximately 76% of BC cases. The mutant type (CC) and heterozygous type (GC) were identified in approximately 10% and 14% of cases, respectively. Among Iraqi women with BC carrying GG, GC, and CC genotypes, no significant differences were found in BC markers (cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)) or paclitaxel-related side effects (neutropenia, oral mucositis, and peripheral neuropathy) at P > 0.05.
Conclusion:
The distribution of the SLCO1B3 767G>C (rs60140950) genotype was high among Iraqi women with BC. No significant correlations were found between the SLCO1B3 767G>C genetic variant and changes in BC markers (CA 15-3 and CEA) or the incidence of early paclitaxel-related adverse effects.
Related Concept Videos
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Drugs that Stabilize Microtubules
Treatment Resistant Cancers
