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Repeatability of Anterior Segment Measurements Using Anterior Segment OCT Combined with Placido Corneal Topography in
Abdulaziz Alsomali1, Musab Abdulaziz Alzoman2, Mohammed Falah Aljasir2
1Ophthalmology Department, College of Medicine, King Faisal University, Alahsa, Saudi Arabia.
Purpose:
To evaluate the repeatability of anterior segment parameters using the MS-39 in patients with dry eye disease.
Methods:
This prospective cross-sectional observational study included 52 eyes from 26 participants with dry eye disease. Each eye underwent three consecutive MS-39 acquisitions within 15 minutes. Repeatability was analyzed using the coefficient of repeatability, coefficient of variation, intraclass correlation coefficient, and repeated-measures analysis of variance.
Results:
Most parameters showed excellent intra-session repeatability (intraclass correlation >0.98, coefficient of variation <15%), except corneal astigmatism (coefficient of variation approximately 52%). Exploratory stratified analyses suggested lower repeatability in eyes with higher Ocular Surface Disease Index scores and lower Tear Break-Up Time values, particularly for corneal astigmatism.
Conclusion:
The MS-39 demonstrates high intra-session repeatability for most anterior segment parameters in dry eye disease. Corneal astigmatism showed greater variability; therefore, astigmatism readings should be interpreted cautiously in patients with ocular surface instability. This study assessed intra-session repeatability only and did not evaluate inter-session reproducibility or performance relative to healthy controls.