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Published on: November 28, 2019
Lactate suppresses STING activation to promote tumor immune evasion
1Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Abstract:
Lactate, known for its metabolic functions, has recently emerged as a signaling molecule. In a recent issue of Immunity, Guo and colleagues report that lactate is a competitive antagonist of STING and propose an epidermal growth factor receptor (EGFR)-mediated signaling cascade that enhances lactate dehydrogenase A (LDHA) activity, lactate production, and immunosuppression.1.
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