Related Experiment Video
Updated: Sep 3, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Continuous Renal Replacement Therapy for Cytokine Storm in Diabetic Kawasaki Shock Syndrome
Zhijiang Zhou1, Ping Ling1, Rong Tang1
1Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, China.
Abstract:
To report the successful use of continuous renal replacement therapy (CRRT) in a child with type 1 diabetes mellitus (T1DM) and intravenous immunoglobulin (IVIG)-refractory Kawasaki disease shock syndrome (KDSS). A 3-year, 10-month-old boy with poorly controlled T1DM and autoimmune thyroiditis presented with KDSS and diabetic ketoacidosis. Despite IVIG and high-dose aspirin, he developed refractory shock and metabolic acidosis. Continuous venovenous hemodiafiltration was initiated, leading to rapid hemodynamic stabilization, resolution of hyperinflammation, and metabolic normalization. CRRT may serve as a rescue therapy in critically ill children with concurrent cytokine storm and metabolic crisis, particularly when standard immunomodulatory therapies fail.
Related Concept Videos
Continuous Renal Replacement Therapy
Acute Kidney Injury V: Interprofessional Care
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Kidney Transplant II: Surgical Procedure