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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Long Non-Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential
Ashlyn Poole1,2, Ingrid Laing1,3,4, Ryan Mead-Hunter2
1Wal-yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.
Abstract:
Asthma affects millions worldwide. Long non-coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma and respiratory illnesses. LncRNA serve important regulatory roles in numerous pathways, especially gene expression. Nuclear paraspeckle assembly transcript 1 (NEAT1) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) are two of the most well-studied lncRNA. This review highlights the current evidence of mechanisms involving lncRNA, particularly NEAT1 and MALAT1, in asthma pathophysiology and viral-induced exacerbations, and as novel targets for therapies targeting asthma, asthma-related symptoms and airway remodelling.
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