Artificial intelligence in emergency medicine: from algorithmic performance to real-world clinical integration -...

Emergency departments (EDs) operate under time pressure, diagnostic uncertainty, and cognitive overload. Artificial intelligence (AI)-driven clinical decision support systems (CDSS) promise to enhance diagnostic accuracy, risk stratification, and workflow efficiency. However, translation from algorithmic performance to bedside integration remains inconsistent.

This narrative review synthesizes current evidence on AI-based CDSS in emergency medicine, focusing on diagnostic performance, clinical impact, and implementation barriers. Literature published between 2015 to December 2025 was reviewed across PubMed, Scopus, and Embase. Applications include AI-assisted triage, sepsis prediction, stroke identification, ECG interpretation, imaging analysis, and ED operational forecasting. Many systems demonstrate strong retrospective performance (AUROC 0.85-0.95) and earlier identification of high-risk patients compared with conventional scoring tools. However, prospective multicenter validation demonstrating mortality reduction or sustained length-of-stay improvement remains limited. Performance degradation across institutions, algorithmic bias, data governance challenges, workflow disruption, alert fatigue, medico-legal ambiguity, and lack of explainability are persistent barriers to adoption. Evidence suggests AI is most effective when deployed as decision augmentation rather than autonomous replacement.

AI-CDSS in emergency medicine demonstrates promising diagnostic capability but limited real-world outcome validation. Future development must prioritize prospective implementation trials, transparent model reporting, clinician engagement, and equitable performance across diverse populations to ensure safe and effective integration into emergency care systems.