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Updated: Sep 3, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Construction of meta-Aryl Acetophenone Derivatives via Pd-Catalyzed Arylation/Dehydrogenative Aromatization
Jiahui Ma1, Qiaoliang Xu1, Yaohang Cheng2
1School of Chemistry and Materials Science, Heilongjiang University, Harbin, 150080, China.
Abstract:
Herein, we report a palladium-catalyzed domino arylation/dehydrogenative aromatization of acylcyclohexenes to synthesize meta-aryl acetophenone derivatives. This strategy achieves a previously elusive formal meta-C-H arylation of ketones, even with heteroaryl halides. It allows the late-stage introduction of fluorophores and supramolecular motifs, and the robustness is demonstrated by converting biaryl compounds to cumulenes and an AIE fluorescent Na+ probe. Mechanistic investigations revealed a radical process involving an aryl radical as a hydrogen atom transfer reagent.
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