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Updated: Sep 3, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Ni-Catalyzed Dechlorodiarylation of gem-Dichloroalkanes
Yang-Jie Mao1, Hui-Jun Ren1, Wei-Kang Huang1
1State Key Laboratory of Green Chemical Synthesis and Conversion, Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou310014, P. R. China.
Abstract:
The difunctionalization of gem-dichloroalkanes enables installation of two functional groups on a single carbon, representing a valuable strategy, yet it has remained challenging. Herein, we report a nickel-catalyzed reductive 1,1-diarylation of gem-dichloroalkanes with aryl bromides under mild conditions. The protocol efficiently constructs diarylalkanes and fluorenes, featuring a broad substrate scope and excellent functional group tolerance. Gram-scale synthesis and facile preparation of medicinally relevant intermediates with diarylalkane skeletons further highlight their practical value.
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