Related Experiment Video
Updated: Sep 3, 2026

Real-World M3-BREATHE: Toward Multimodal Mobile Monitoring of Behaviour, Respiration, and Exposures for Treatment and Health Evaluation
Published on: June 5, 2026
Migration-driven exposome reconfiguration: a predictive, preventive and personalized medicine perspective on
Livia Alvarenga1, Ribanna Aparecida Marques Braga2, Júlia Galbiati de Souza2
1Department of Cardiopneumology, Faculty of Medicine (FMUSP), University of São Paulo, São Paulo, SP Brazil.
Abstract:
Contemporary global migration, driven by socioeconomic instability, armed conflict, climate change, and political factors, has emerged as a major determinant of exposome reconfiguration and cardiometabolic vulnerability. Migrant populations are disproportionately exposed to cumulative environmental, psychosocial, behavioral, and cultural stressors that may contribute to chronic low-grade inflammation, neuroendocrine dysregulation, metabolic dysfunction, and increased cardiovascular disease (CVD) risk across the life course. Within the framework of predictive, preventive, and personalized medicine (PPPM/3 PM), migration should not be viewed solely as a demographic phenomenon, but rather as a dynamic process capable of reshaping individual exposure profiles and biological responses. Environmental pollution, dietary acculturation, psychosocial stress, sleep disruption, climate-related exposures, social vulnerability, and barriers to healthcare interact to modulate the gut-brain axis, microbiota composition, inflammatory pathways, and cardiometabolic outcomes. This narrative review discusses migration as a driver of exposome-mediated cardiovascular risk and explores how exposome science may support risk stratification, early identification of vulnerable populations, and targeted preventive strategies in migrant individuals. Furthermore, we discuss the potential role of biomarkers, digital health technologies, and multi-omics approaches in enabling more personalized and culturally sensitive interventions. By integrating migration, exposome science, and PPPM principles, this review proposes a shift from generalized, reactive healthcare models toward more proactive, mechanism-based, and precision-oriented approaches to cardiometabolic prevention in migrant populations.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Type II Diabetes I: Introduction
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics and Pharmacogenomics: Overview
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenetics of Drug Metabolism: Overview