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Updated: Sep 3, 2026
Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
Deep eutectic solvent-enabled green synthesis of gold nanoparticle-decorated ZIF-L composites for colorimetric
Trung Hieu Vu1,2, Ngoc Xuan Dat Mai1,2, Nhu Hoa Thi Tran2,3
1Advanced Materials Technology Institute, Vietnam National University Ho Chi Minh City Ho Chi Minh City 70000 Vietnam tktloan@inomar.edu.vn.
Abstract:
Developing environmentally friendly synthesis strategies for metal-organic frameworks (MOF) and their hybrid nanocomposites is critical to creating sustainable, high-performance materials for analytical sensing applications. In this study, a gold nanoparticle-decorated ZIF-L (ZIF-L/Au) composite was synthesized via a deep eutectic solvent (DES)-assisted green synthesis, thereby providing enhanced stability and improved dispersion of Au nanoparticles and minimizing the use of hazardous organic solvents. The DES-stabilized ZIF-L/Au composite exhibited strong peroxidase-like activity toward ABTS˙+ radical scavenging, effectively decolorizing it from green to transparent. Notably, the presence of trimethoprim (TMP) inhibited this catalytic decolorization, leading to a concentration-dependent restoration of the green color. Under optimized conditions, the ZIF-L/Au composite enabled colorimetric detection of TMP with high sensitivity and selectivity, with a limit of detection of 4.38 nM. This work provides a sustainable strategy for constructing functional MOF-based hybrid nanomaterials and demonstrates their strong potential for practical, on-site monitoring of antibiotic residues.
