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Updated: Sep 3, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Clinical Benefit of Pembrolizumab in Lynch Syndrome-Associated Advanced Ovarian Cancer With Germline MSH6 Variant: A
Tomomi Yokozawa1,2, Sayako Nakagawa1, Yukio Suzuki1,2
1Department of Gynecology Kanagawa Cancer Center Yokohama Japan.
Abstract:
This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first-line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.
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