Outstanding Reviewers for RSC Medicinal Chemistry in 2023

    RSC Medicinal Chemistry
    |September 2, 2026
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    Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn stereochemistry.
    Positive Regulator Molecules01:45

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    To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
    Photochemical Electrocyclic Reactions: Stereochemistry01:26

    Photochemical Electrocyclic Reactions: Stereochemistry

    The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
    Selection Rules: Photochemical Activation
    Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration02:34

    Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

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    Molecules with Multiple Chiral Centers02:25

    Molecules with Multiple Chiral Centers

    Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
    Quantitative Aspects of Drug-Receptor Interaction01:30

    Quantitative Aspects of Drug-Receptor Interaction

    The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...