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Updated: Sep 4, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Immunosuppression in the Pathophysiology of Sepsis
Tristan Couwenbergh1, Wouter A van der Heijden2, Mihai G Netea3
1Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Abstract:
Sepsis-induced immunosuppression contributes to mortality, increased susceptibility to secondary infections and long-term complications. Myeloid cells undergo functional reprogramming, while adaptive immune cells, particularly T lymphocytes, show altered composition and lymphopenia. This immunosuppression is driven by several mechanisms. Therapies, including immune-stimulating cytokines, checkpoint inhibitors, and mesenchymal stem cells, are under investigation to restore immune function, but their effectiveness in clinical practice is still unclear.
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