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Updated: Sep 4, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Considerations for the dynamic role of bile acids during oral drug discovery and development
Zahraa Al-Tamimi1, Michael J Hageman2,3
1Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
Abstract:
Knowledge of gastrointestinal media is crucial for developing successful oral drug products. Bile acids are an essential component in the intestinal lumen, influencing the behavior of orally administered molecules. This review addresses the various roles of bile acids in drug discovery and development, examines the differences between humans and various preclinical models, and discusses how the physicochemical properties of drug molecules may influence their interactions with bile-containing media.
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