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Updated: Sep 4, 2026

Nanofibrillar Basement Membrane Mimic Made of Recombinant Functionalized Spider Silk in Custom-Made Tissue Culture Inserts
Published on: November 1, 2024
Spider-Silk-Inspired Hierarchical Nanofiber Architectures Enabling Environmentally Robust Multifunctional Sensing for
Youwei Zhao1, Xinyuan Zhang1, Wanqing Liu1
1National & Local Joint Engineering Research Center of Metrology Instrument and system, Hebei Key Laboratory of Energy Metering and Safety Testing Technology, Baoding, College of Quality and Technical Supervision, Hebei University, Baoding071002, China.
Abstract:
Electrooculography (EOG) offers a direct electrophysiological window for objective fatigue assessment under prolonged visual load. However, skin-mounted EOG sensors face an inherent trade-off between maintaining signal stability and ensuring long-term wearability and skin comfort. Herein, inspired by spider-silk architectures, we report an environmentally robust, multifunctional EOG-fusion sensor based on a hierarchically engineered, cavity-structured bioelectrode that integrates an uncarbonized PAN@MXene-ZIF spacer with a carbonized conductive core. This state-engineered architecture enables simultaneous EOG, electromyography (EMG) and pressure sensing, while providing outstanding bioprotection (cell viability >99.5%) and broadband optical shielding (99.5% UV and 99.9% NIR blocking), together with microwave absorption (RLmin = [-59] dB, EAB of 1.26 GHz (X band)). The pressure channel delivers high sensitivity (345.08 kPa-1), rapid response/recovery (80/80 ms) and an ultralow detection limit of 20 Pa. The low-impedance bioelectric interface uses lightweight 1D-CNN and BiLSTM models, combined with data processing techniques, to achieve 94.21% accuracy in recognizing 9 types of eye movement patterns and effectively assess the degree of visual fatigue in immersive VR environments.
