A Bayesian Multi-State Data Integration Approach for Estimating County-Level Prevalence of Opioid Misuse in the...

Drug overdose deaths, including from opioids, remain a significant public health threat to the United States (US). To abate the harms of opioid misuse, understanding its prevalence at the local level is crucial for stakeholders in communities to develop response strategies that effectively use limited resources. Although there exist several state-specific studies that provide county-level prevalence estimates, such estimates are not widely available across the country, as the datasets used in these studies are not always readily available in other states, which, therefore, has limited the wider applications of existing models. To fill this gap, we propose a Bayesian multi-state data integration approach that fully utilizes publicly available data sources to estimate county-level opioid misuse prevalence for all counties in the US. The hierarchical structure jointly models opioid misuse prevalence and overdose death outcomes, leverages existing county-level prevalence estimates in limited states and state-level estimates from national surveys, and accounts for heterogeneity across counties and states with counties' covariates and mixed effects. Furthermore, our parsimonious and generalizable modeling framework employs horseshoe+ prior to flexibly shrink coefficients and prevent overfitting, ensuring adaptability as new county-level prevalence data in additional states become available. Using real-world data, our model shows high estimation accuracy through cross-validation and provides nationwide county-level estimates of opioid misuse for the first time.